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Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1541-8

Abstract: List>

● Perfluorooctanesulfonic acid and perfluorooctanoic acid highest in humanmilk.

Keywords： Human biomonitoring     Human breast milk     LC-MS/MS analysis     Lifestyle parameters    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 179-184 doi: 10.15302/J-FASE-2014020

Abstract: Due to the limited yield of human BCHE (hBCHE) when purifying from human plasma, it is necessary to findOne potential method is to produce transgenic livestock that make modified milk containing high concentrationIn this study, we cloned the gene into a human lactoferrin (hLF) bacterial artificial chromosome (BACexpressed efficiently in the mammary gland of the transgenic mice and the concentration of rhBCHE in the milk

Keywords： recombinant human butyrylcholinesterase (rhBCHE)     human lactoferrin bacterial artificial chromosome (hLFBAC)     transgenic mice     milk    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: is an ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breastHowever, the role of MID2 in breast cancer remains unknown.This study investigated the expression, prognostic value, and role of MID2 in breast cancer.cell lines compared with that in normal breast epithelial cells and paired adjacent non-tumor tissueanalysis demonstrated that MID2 was overexpressed in 272 of 284 (95.8%) paraffin-embedded, archived breast

Keywords： breast cancer     MID2     proliferation     overall survival     xenograft    

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Construction of a universal recombinant expression vector that regulates the expression of human lysozymein milk

Shen LIU, Shengzhe SHANG, Xuezhen YANG, Huihua ZHANG, Dan LU, Ning LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 382-389 doi: 10.15302/J-FASE-2018211

Abstract: A key component in the technology is the construction of an efficient milk expression vector.>) was modified twice by homologous recombination to produce a universal expression vector, and the humanfertilized mouse embryos, to successfully generate two transgenic mouse lines that expressed recombinant humanlysozyme (rhLZ) in milk.that the resulting vector regulates the expression of hLZ in milk.

Keywords： BAC recombinant methods     gene expression     human lysozyme     transgenic mice     milk expression vector    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials    

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Global warming potential associated with Irish milk powder production

William Finnegan, Jamie Goggins, Aksana Chyzheuskaya, Xinmin Zhan

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 3, doi: 10.1007/s11783-017-0949-z

Abstract: Therefore, in this paper, a single agri-food product, milk powder, is examined in order to estimate theA cradle-to-processing factory gate analysis, which includes raw milk production, raw milk transportationThe factories surveyed processed approximately 24% of the total raw milk processed in the Republic ofThe average total GWP associated with the manufacture of milk powder is 9.731 kg CO eq·kg milk powder, which has a standard deviation of 2.26 kg CO eq·kg milk powder, for the life cycle stages analyzed

Keywords： Dairy     Global warming potential     Ireland     Life cycle assessment     Milk powder     Milk production    

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Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 1-10 doi: 10.1007/s11684-020-0741-5

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous

Keywords： triple-negative breast cancer     immunotherapy     targeted therapy    

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How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 290-293 doi: 10.1007/s11684-010-0093-7

Abstract: The relevance of postmenopausal hormone therapy (HT) for breast cancer risk has been long debated, althoughThese unanswered questions include: whether HT has a positive impact on breast cancer; whether riskscancer; breast cancer in postmenopausal women using HT usually has better prognosis than that of nonusersHowever, a possible risk of breast cancer associated with long-term HT usage should not be ignored.With respect to prevention of breast cancer, regular evaluation of individual breast cancer susceptibility

Keywords： breast cancer     postmenopausal hormone therapy     unopposed estrogen therapy     combined estrogen-progestin therapy    

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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer is one of the most common malignancies that seriously threaten women’s health.In the process of the malignant transformation of breast cancer, metabolic reprogramming and immune evasionBreast cancer cells generate energy through increased glucose metabolism.For tumor-associated immunity, poor immunogenicity and heightened immunosuppression cause breast cancerinvestigated, and the genes involved in these processes are used as clinical therapeutic targets for breast

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 452-458 doi: 10.1007/s11684-009-0080-z

Abstract: studies that addressed whether reproductive factors and oral contraceptive use were associated with breast#8220;*”: summary OR was adjusted; 95% CI, 1.24―3.62) were correlated with the increase in breast(OR, 0.76; 95% CI, 0.64―0.90) indicated no association with breast cancer risk.Menopausal age >50yr and oral contraceptive use are positively correlated with an increase in breastcancer risk while breast-feeding and number of full-term pregnancies ≥1 are protective factors

Keywords： meta-analysis     breast cancer     risk factors     reproductive factors     oral contraceptive use    

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Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 426-430 doi: 10.1007/s11684-009-0085-7

Abstract: This study is mainly aimed at evaluating the expression of PC-cell-derived growth factor (PCDGF) in breastcancer and breast adenofibroma, and to compare with other commonly used clinical pathological indices, then to investigate the diagnostic and targeted therapeutic purpose of PCDGF in breast cancer tissueWe found that PCDGF was expressed in most breast cancer tissue, but was not in breast adenofibroma tissuetarget of therapy for breast cancer.

Keywords： PC-cell-derived growth factor     breast neoplasms     clinical markers    

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A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 112-116 doi: 10.1007/s11684-014-0345-z

Abstract:

Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer.In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was

Keywords： neuroendocrine carcinoma     neo-adjuvant therapy     breast    

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frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: We further tested FAK splicing variants in breast neuroendocrine carcinoma (BrNECs), and found>6/7 was positive in 14 (93.3%) of 15 BrNECs but 0 in 23 non-NEC breastprotein 4 (SRRM4) was overexpressed in FAK6/7-positive pancreatic tumors and breast

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 482-489 doi: 10.1007/s11705-013-1342-5

Abstract: decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breastThe pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line

Keywords： pectic extracts     antiproliferative activity     breast cancer     enzymatic treatment    

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Title Author Date Type Operation

Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Journal Article

Construction of a universal recombinant expression vector that regulates the expression of human lysozymein milk

Shen LIU, Shengzhe SHANG, Xuezhen YANG, Huihua ZHANG, Dan LU, Ning LI

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

Global warming potential associated with Irish milk powder production

William Finnegan, Jamie Goggins, Aksana Chyzheuskaya, Xinmin Zhan

Journal Article

Progress in systemic therapy for triple-negative breast cancer

Hongnan Mo, Binghe Xu

Journal Article

How to judge the association of postmenopausal hormone therapy and the risk of breast cancer

Ling XU

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

Meta-analysis of the risk factors of breast cancer concerning reproductive factors and oral contraceptive

Qiong DAI MD, Bei LIU MD, Yukai DU MM,

Journal Article

Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Journal Article

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Journal Article

frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas and breast

Journal Article

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Journal Article